Extracts of Edible Plants Inhibit Pancreatic Lipase, Cholesterol Esterase and Cholesterol Micellization, and Bind Bile Acids

Food Technology and Biotechnology

Kittana Mäkynen¹  Sirichai Adisakwattana²  Benjanut Chanathong²  Araya Hemrid³  Julnaryn Intrawangso³ 

[1] Research Group of Herbal Medicine for Prevention and Therapeutic of Metabolic Diseases, Chulalongkorn University, Pathumwan, 10330 Bangkok, Thailand;The Medical Food Research and Development Center, Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Pathumwan, 10330 Bangkok, Thailand;Undergraduate Program in Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Pathumwan, 10330 Bangkok, Thailand;

关键词: edible plants;    pancreatic lipase;    cholesterol micellization;    pancreatic cholesterol esterase;    bile acid binding;   

DOI  :  

来源: DOAJ

【 摘 要 】

The application of edible plants with more effective ability to inhibit fat digestion and absorption has recently been explored for possible treatment of hyperlipidaemia. The aim of the present study is to investigate the effect of nine edible plants on the inhibition of pancreatic lipase and pancreatic cholesterol esterase activities, as well as the inhibition of cholesterol micelle formation, and bile acid binding. Our findings have shown strong pancreatic lipase inhibitory activity and the inhibition of cholesterol micellization by mulberry leaf extract. Safflower extract was the most potent inhibitor of pancreatic cholesterol esterase. In addition, cat’s whiskers and safflower extracts had a potent bile acid binding activity. It is suggested that a daily intake of these edible plants may delay postprandial hypertriacylglycerolaemia and hypercholesterolaemia, and therefore may be applied for the prevention and treatment of hyperlipidaemia.

【 授权许可】

Unknown