New Strategies for Rehabilitation and Pharmacological Treatment of Fatigue Syndrome in Multiple Sclerosis

Journal of Clinical Medicine

Joanna Kostka¹  Elżbieta Miller²  Ewa Zielińska-Nowak²  Lidia Włodarczyk³ 

[1] Department of Gerontology, Medical University of Lodz, Milionowa 14, 90-001 Lodz, Poland;Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 90-001 Lodz, Poland;Department of Occupational Diseases and Environmental Health, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland;

关键词: multiple sclerosis;    fatigue;    pharmacological treatment;    rehabilitation;    physical activity;    aerobic training;   

DOI  :  10.3390/jcm9113592

来源: DOAJ

【 摘 要 】

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS), with an inflammatory demyelinating basis and a progressive course. The course of the disease is very diverse and unpredictable. Patients face many problems on a daily basis, such as problems with vision; sensory, balance, and gait disturbances; pain; muscle weakness; spasticity; tremor; urinary and fecal disorders; depression; and rapidly growing fatigue, which significantly influences quality of life among MS patients. Excessive fatigue occurs in most MS patients in all stages of this disease and is named MS-related fatigue. The crucial issue is the lack of effective treatment; therefore, this review focuses not only on the most common treatment methods, but also on additional novel therapies such as whole-body cryotherapy (WBC), functional electrical stimulation (FES), and non-invasive brain stimulation (NIBS). We also highlight the advantages and disadvantages of the most popular clinical scales used to measure fatigue. The entire understanding of the origins of MS-related fatigue may lead to the development of more effective strategies that can improve quality of life among MS patients. A literature search was performed using MEDLINE, EMBASE, and PEDro databases.

【 授权许可】

Unknown