The Road not Taken: Less Traveled Roads from the TGN to the Plasma Membrane

Membranes

Anne Spang¹ 

[1] Biozentrum: Growth & Development, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland;

关键词: membrane transport;    vesicle transport;    trans-Golgi network;    exocytosis;    secretion;    adaptor complex;    small GTPase;   

DOI  :  10.3390/membranes5010084

来源: DOAJ

【 摘 要 】

The trans-Golgi network functions in the distribution of cargo into different transport vesicles that are destined to endosomes, lysosomes and the plasma membrane.Over the years, it has become clear that more than one transport pathway promotes plasma membrane localization of proteins. In spite of the importance of temporal and spatial control of protein localization at the plasma membrane, the regulation of sorting into and the formation of different transport containers are still poorly understood. In this review different transport pathways, with a special emphasis on exomer-dependent transport, and concepts of regulation and sorting at the TGN are discussed.

【 授权许可】

Unknown