Kidney stone formation and antioxidant effects of Cynodon dactylon decoction in male Wistar rats

Avicenna Journal of Phytomedicine

Abbasali Abbasnezhad¹  Nema Mohamadian Roshan²  Roghayeh Pakdel³  Seyed Mojtaba Mousavi³  Batool Zarei⁴  Parichehr Hayatdavoudi⁵  Mousa AL-Reza Hadjzadeh⁵  Abolfazl Khajavi Rad⁶  Azita Aghaee⁷  Alireza Golshan⁸ 

[1] Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad,Iran;Department of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhd, Iran;Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran;Department of physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;Neurocognitive Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;Neurogenic Inflammation Research Center,Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;Pharmacological Research Center of Medicinal Plants, Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran;School of Medicine, North Khorasan University of Medical sciences, Bojnurd, Iran;

关键词: Cynodon dactylon decoction;    FRAP;    MDA;    Nephrolithiasis;    Antioxidant;    Ethylene glycol;   

DOI  :  10.22038/ajp.2016.7844

来源: DOAJ

【 摘 要 】

Objectives: The antioxidant capacity impairs in kidney and urinary bladder of animals with stone disease. Herbal medicine can improve the antioxidant condition of renal tissue. Cynodon dactylon (C. dactylon) is a medicinal plant with antioxidative and diuretic properties and different preparations of this plant have shown promising effects in stone disease. Assessment of the whole plant decoction to prevent kidney stone disease as well as its antioxidant effects was the aim of this paper.Materials and Methods: Fifty male Wistar rats were randomly divided into 5 experimental groups (n=10). One group was left without treatment and four groups received ethylene glycol (1% v/v) in drinking water for 6 weeks. Three doses of Cynodon dactylon aqueous decoction (12.5, 50 and 200 mg/kg BW) were added to the drinking water of groups 3-5. Finally, water intake, 24-hour urine volume, MDA, total thiol concentration and FRAP value were measured in the serum and kidney tissues. The CaOx depositions were evaluated by hematoxylin and eosin staining.Results: Compared to the ethylene glycol-treated group, 200 mg/kg C. dactylon, lowered stone incidents, decreased urine volume, increased FRAP/g Cr (43%) and thiol content (p

【 授权许可】

Unknown