Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer

Antioxidants

Petr Slama¹  Kavindra Kumar Kesari²  Nishat Fatima³  Shubhadeep Roychoudhury⁴  Syed Shabihe Raza Baqri⁵  Sharmila Fagoonee⁶  Ahmad Alsulimani⁷  Shafiul Haque⁸ 

[1] Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, 61300 Brno, Czech Republic;Department of Applied Physics, School of Science, Aalto University, 00076 Espoo, Finland;Department of Chemistry, Shia PG College, Lucknow 226003, India;Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India;Department of Zoology, Shia PG College, Lucknow 226003, India;Institute of Biostructure and Bioimaging (CNR), Molecular Biotechnology Center, 10124 Turin, Italy;Medical Laboratory Technology Department, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia;Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia;

关键词: ethnomedicine;    oxidative stress;    ROS;    cancer;    phytochemicals;   

DOI  :  10.3390/antiox10101606

来源: DOAJ

【 摘 要 】

Oxygen is indispensable for most organisms on the earth because of its role in respiration. However, it is also associated with several unwanted effects which may sometimes prove fatal in the long run. Such effects are more evident in cells exposed to strong oxidants containing reactive oxygen species (ROS). The adverse outcomes of oxidative metabolism are referred to as oxidative stress, which is a staple theme in contemporary medical research. Oxidative stress leads to plasma membrane disruption through lipid peroxidation and has several other deleterious effects. A large body of literature suggests the involvement of ROS in cancer, ageing, and several other health hazards of the modern world. Plant-based cures for these conditions are desperately sought after as supposedly safer alternatives to mainstream medicines. Phytochemicals, which constitute a diverse group of plant-based substances with varying roles in oxidative reactions of the body, are implicated in the treatment of cancer, aging, and all other ROS-induced anomalies. This review presents a summary of important phytochemicals extracted from medicinal plants which are a part of Indian ethnomedicine and Ayurveda and describes their possible therapeutic significance.

【 授权许可】

Unknown