Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise

Cells

Kent W. Jorgenson¹  Wenyuan G. Zhu¹  Jamie E. Hibbert¹  Kuan Hung Lin¹  Troy A. Hornberger¹  Nathaniel D. Steinert¹  Jake L. Lemens¹  Sarah M. Newman²  Dudley W. Lamming² 

[1] Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA;Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA;

关键词: skeletal muscle;    hypertrophy;    myonuclear accretion;    protein synthesis;    signaling;    growth;   

DOI  :  10.3390/cells10092459

来源: DOAJ

【 摘 要 】

This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 repetitions per set, 2 min of rest between sets, approximately two maximal-intensity sets per session, last set taken to failure, and a progressive increase in loading that is based on the individual’s performance). We demonstrate that weight pulling can induce an increase in the mass of numerous muscles throughout the body. The relative increase in muscle mass is similar to what has been observed in human studies, and is associated with the same type of long-term adaptations that occur in humans (e.g., fiber hypertrophy, myonuclear accretion, and, in some instances, a fast-to-slow transition in Type II fiber composition). Moreover, we demonstrate that weight pulling can induce the same type of acute responses that are thought to drive these long-term adaptations (e.g., the activation of signaling through mTORC1 and the induction of protein synthesis at 1 h post-exercise). Collectively, the results of this study indicate that weight pulling can serve as a highly translatable mouse model of progressive resistance exercise.

【 授权许可】

Unknown