Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality

Frontiers in Psychiatry

Ting Ma¹  Huimei An²  Wenxuan Zhao²  Fude Yang²  Zhiren Wang²  Yajun Yun²  Qi Zhang² 

[1] College of Basic Medical and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China;Peking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Beijing, China;

关键词: gut microbiome;    major depressive disorder;    sleep quality;    16S rRNA sequencing;    insomnia;   

DOI  :  10.3389/fpsyt.2021.645045

来源: DOAJ

【 摘 要 】

The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on the gut microbiota in MDD are inconsistent, and data on MDD's effects on sleep are lacking. This study aimed to analyze the gut microbiota composition and sleep quality of patients with MDD. We performed 16S rRNA sequencing of stool samples from 36 patients with MDD and 45 healthy controls (HC). Sleep quality was assessed using the Pittsburgh Sleep Quality Index, depressive severity with the Hamilton Depression Scale, and insomnia severity using the Insomnia Severity Index. Forty-eight microbiota targets showed significant differences between MDD and HC. In MDD, six microbiota targets were associated with the severity of depression, 11 with sleep quality, and 3 with sleep severity. At the genus level, Dorea was simultaneously related to depression and sleep quality, while Intestinibacter was more closely related to sleep problems. Coprococcus and Intestinibacter were associated with sleep quality independent of the severity of depression. In conclusion, the present findings enable a better understanding of the relationship between gut microbiota and MDD-related symptoms. Gut microbiota alterations may become potential biomarkers and/or treatment targets for sleep quality in MDD.

【 授权许可】

Unknown