Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Journal of Clinical Medicine

Hiroshi Sakaue¹  Rie Tsutsumi¹  Kanako Hara¹  Jun Oto²  Nobuto Nakanishi²  Masafumi Matsuo³ 

[1] Department of Nutrition and Metabolism, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto, Tokushima 770-8503, Japan;Emergency and Critical Care Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima 770-8503, Japan;Research Center for Locomotion Biology, Kobe Gakuin University, 518 Arise, Ikawadani, Nishi, Kobe 651-2180, Japan;

关键词: titin;    muscle;    diaphragm;    atrophy;    physical dysfunction;    biomarker;   

DOI  :  10.3390/jcm10040614

来源: DOAJ

【 摘 要 】

Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.

【 授权许可】

Unknown