A case study of voltage-gated potassium channel antibody-related limbic encephalitis with PET/MRI findings

Epilepsy and Behavior Case Reports

关键词: Voltage-gated potassium channel;    Limbic encephalitis;    Autoimmune epilepsy;    Positron emission tomography;    Magnetic resonance imaging;    PET/MRI;   

DOI  :  10.1016/j.ebcr.2015.02.002

来源: DOAJ

【 摘 要 】

Preclinical and clinical studies have demonstrated the significance of inflammation and autoantibodies in epilepsy, and the use of immunotherapies in certain situations has become an established practice. Temporal lobe epilepsy can follow paraneoplastic or nonparaneoplastic limbic encephalitis associated with antibodies directed against brain antigens. Here, we focus on a patient with worsening confusion and temporal lobe seizures despite treatment with antiepileptic medications. Serial brain MRIs did not conclusively reveal structural abnormalities, so the patient underwent brain PET/MRI to simultaneously evaluate brain structure and function, revealing bitemporal abnormalities. The patient was diagnosed with voltage-gated potassium channel antibody-related limbic encephalitis based on clinical presentation, imaging findings, and antibody testing. Treatment included the addition of a second antiepileptic agent and oral steroids. His seizures and cognitive deficits improved and stabilized.

【 授权许可】

Unknown