Prospective Application of Ferroptosis in Hypoxic Cells for Tumor Radiotherapy

Antioxidants

Lingbin Meng¹  Zhuangzhuang Zheng²  Qin Zhao²  Xin Jiang²  Huanhuan Wang²  Chenbin Bian²  Jing Su²  Ying Xin³ 

[1] Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA;Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun 130021, China;Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China;

关键词: hypoxia;    ferroptosis;    reactive oxygen species (ROS);    lipid peroxidation;    radiotherapy;    Nrf-2;   

DOI  :  10.3390/antiox11050921

来源: DOAJ

【 摘 要 】

Radiation therapy plays an increasingly important role in cancer treatment. It can inhibit the progression of various cancers through radiation-induced DNA breakage and reactive oxygen species (ROS) overload. Unfortunately, solid tumors, such as breast and lung cancer, often develop a hypoxic microenvironment due to insufficient blood supply and rapid tumor proliferation, thereby affecting the effectiveness of radiation therapy. Restraining hypoxia and improving the curative effect of radiotherapy have become difficult problems. Ferroptosis is a new type of cell death caused by lipid peroxidation due to iron metabolism disorders and ROS accumulation. It plays an important role in both hypoxia and radiotherapy and can enhance the radiosensitivity of hypoxic tumor cells by amplifying oxidative stress or inhibiting antioxidant regulation. In this review, we summarize the internal relationship and related mechanisms between ferroptosis and hypoxia, thus exploring the possibility of inducing ferroptosis to improve the prognosis of hypoxic tumors.

【 授权许可】

Unknown