Matricsins 2, 7 and 9 in breast tumors. determination of posibile connection with the concentration of HER-2/neu

RUDN Journal of Medicine

N E Kushlinskii¹  I V Tereshkina¹  Т Т Berezov²  N N Chernov²  O M Kuznetsova²  A Y Nazarenko²  Yu V Kryuk² 

[1] Российский онкологический научный центр им. Н.Н. Блохина РАМН;Российский университет дружбы народов;

关键词: металлопротеиназы;    иммуноферментный анализ;    рак молочной железы;    белок her-2/neu;    рецепторы половых гормонов;   

DOI  :  

来源: DOAJ

【 摘 要 】

The comparative analysis of the quantity of matrix metalloproteinases (MMP) 2,7 and 9 in breast cancer is carried out; the concentration of sex hormones receptors and protein HER-2/neu are determined. Authentically high values MMP-2 and MMP-7 are found in a tumor tissue in contrast to the normal one. The elevated concentration of ММР-2 in a tumor is connected with receptor status (p < 0,05). The highest values of concentration ММР-7 and ММP- 9 are found at RE-, RP- and HER-2/neu + tumors, and also in the tumors with the size more than 4,0 cm.

【 授权许可】

Unknown