Pleiotropic Roles of Non-Coding RNAs in TGF-β-Mediated Epithelial-Mesenchymal Transition and Their Functions in Tumor Progression

Cancers

Simon Grelet¹  Philip H. Howe¹  Ariel McShane²  Renaud Geslain² 

[1] Department of Biochemistry and Molecular Biology, MUSC, Charleston, SC 29425, USA;Laboratory of tRNA Biology, Department of Biology, College of Charleston, Charleston, SC 29424, USA;

关键词: epithelial-mesenchymal transition;    tumor progression;    metastasis;    TGF-β;    non-coding RNA;    tRNA;    post-transcriptional regulation;   

DOI  :  10.3390/cancers9070075

来源: DOAJ

【 摘 要 】

Epithelial-mesenchymal transition (EMT) is a spatially- and temporally-regulated process involved in physiological and pathological transformations, such as embryonic development and tumor progression. While the role of TGF-β as an EMT-inducer has been extensively documented, the molecular mechanisms regulating this transition and their implications in tumor metastasis are still subjects of intensive debates and investigations. TGF-β regulates EMT through both transcriptional and post-transcriptional mechanisms, and recent advances underline the critical roles of non-coding RNAs in these processes. Although microRNAs and lncRNAs have been clearly identified as effectors of TGF-β-mediated EMT, the contributions of other atypical non-coding RNA species, such as piRNAs, snRNAs, snoRNAs, circRNAs, and even housekeeping tRNAs, have only been suggested and remain largely elusive. This review discusses the current literature including the most recent reports emphasizing the regulatory functions of non-coding RNA in TGF-β-mediated EMT, provides original experimental evidence, and advocates in general for a broader approach in the quest of new regulatory RNAs.

【 授权许可】

Unknown