Construction of Multiple Logic Circuits Based on Allosteric DNAzymes

Biomolecules

Nikola Kasabov¹  Qiang Zhang²  Xun Zhang²  Yao Yao²  Yuan Liu²  Xin Liu² 

[1] Knowledge Engineering and Discovery Research Institute, Auckland University of Technology, Auckland 1010, New Zealand;School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China;

关键词: DNA computing;    allosteric DNAzymes;    logic circuits;    threshold control;    strand displacement;   

DOI  :  10.3390/biom12040495

来源: DOAJ

【 摘 要 】

In DNA computing, the implementation of complex and stable logic operations in a universal system is a critical challenge. It is necessary to develop a system with complex logic functions based on a simple mechanism. Here, the strategy to control the secondary structure of assembled DNAzymes’ conserved domain is adopted to regulate the activity of DNAzymes and avoid the generation of four-way junctions, and makes it possible to implement basic logic gates and their cascade circuits in the same system. In addition, the purpose of threshold control achieved by the allosteric secondary structure implements a three-input DNA voter with one-vote veto function. The scalability of the system can be remarkably improved by adjusting the threshold to implement a DNA voter with 2n + 1 inputs. The proposed strategy provides a feasible idea for constructing more complex DNA circuits and a highly integrated computing system.

【 授权许可】

Unknown