Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin

Polymers

Inés Ardao¹  Carmen Alvarez-Lorenzo²  Clara López-Iglesias²  CarlosA. García-González²  Irina Smirnova³  Joana Barros⁴  FernandoJ. Monteiro⁴  Pavel Gurikov⁵ 

[1] BioFarma Research group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain;Department of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, Agrupación Estratégica de Materiales (AeMAT) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain;Institute of Thermal Separation Processes, Hamburg University of Technology, Eißendorfer Str. 38, 21073 Hamburg, Germany;Instituto de Investigação e Inovação em Saúde (i3S), Instituto Nacional de Engenharia Biomédica (INEB) and Faculdade de Engenharia Universidade do Porto (FEUP), Universidade do Porto, 4200-135 Porto, Portugal;Laboratory for Development and Modelling of Novel Nanoporous Materials, Eißendorfer Str. 38, 21073 Hamburg, Germany;

关键词: biopolymers;    polymer processing;    biomedical applications;    wound treatment;    chitosan;    aerogels;   

DOI  :  10.3390/polym12020273

来源: DOAJ

【 摘 要 】

Biopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based aerogels in the form of microparticles are of special interest for wound treatment and can also be loaded with bioactive agents to improve the healing process. However, the production of the precursor gel may be limited by the viscosity of the polysaccharide initial solution. The jet cutting technique is regarded as a suitable processing technique to overcome this problem. In this work, the technological combination of jet cutting and supercritical drying of gels was assessed to produce chitosan aerogel microparticles loaded with vancomycin HCl (antimicrobial agent) for wound healing purposes. The resulting aerogel formulation was evaluated in terms of morphology, textural properties, drug loading, and release profile. Aerogels were also tested for wound application in terms of exudate sorption capacity, antimicrobial activity, hemocompatibility, and cytocompatibility. Overall, the microparticles had excellent textural properties, absorbed high amounts of exudate, and controlled the release of vancomycin HCl, providing sustained antimicrobial activity.

【 授权许可】

Unknown