Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Keith A. Johnson¹  Paige Sparks¹  Kathryn V. Papp²  Aaron P. Schultz²  Reisa A. Sperling²  Dorene M. Rentz²  Rebecca E. Amariglio²  Michael Properzi²  Rachel Buckley²  Aubryn Samaroo²  Samantha Burnham³ 

[1] Department of Neurology Brigham and Women's Hospital Boston Massachusetts USA;Department of Neurology Massachusetts General Hospital Boston Massachusetts USA;Health Commonwealth Scientific and Industrial Research Organization (CSIRO) Health and Biosecurity Parkville Victoria Australia;

关键词: amyloid PET;    computerized testing;    digital biomarkers;    learning curves;    practice effects;    preclinical Alzheimer's disease;   

DOI  :  10.1002/dad2.12132

来源: DOAJ

【 摘 要 】

Abstract Introduction We determine whether diminished Learning Over Repeated Exposures (LORE) identifies subtle memory decrements in cognitively unimpaired (CU) older adults with Alzheimer's disease (AD) biomarker burden. Methods Ninety‐four CU participants (mean age = 77.6 ± 5.02) completed a challenging associative memory test, at home, monthly, for up to 1 year (mean = 9.97 months) on a study‐issued iPad. Learning curves for face‐name memory were computed for two versions completed monthly: same face‐name pairs (A‐A‐A) and alternate face‐name pairs (B‐C‐D). Positron emission tomography (PET) imaging characterized global amyloid (Pittsburgh Compound‐B (PiB); amyloid beta (Aβ)+/−) and regional tau burden (flortaucipir). Results Diminished LORE for same (but not alternate) face‐name pairs was associated with greater amyloid and tau burden. Aβ+/− group differences for same face‐name pairs emerged by the fourth exposure and was of medium‐to‐large magnitude (Cohen's d = 0.66; 95% confidence interval [CI] = 0.25‐1.08). Discussion Subtle decrements in learning related to AD pathological burden in CU are detectable over short time‐intervals (ie, months). Implications for prevention trial design are discussed.

【 授权许可】

Unknown