Glycemic Memory as a Pathogenic Basis for Modern Antidiabetic Therapy Algorithm Forming

Mìžnarodnij Endokrinologìčnij Žurnal

M.Yu. Gorshunskaya¹  N.S. Krasova²  V.V. Poltorak² 

[1] Kharkiv Medical Academy of Postgraduate Education, Kharkiv;State Institution «Institute of Problems of Endocrine Pathology named after V.Ya. Danilevsky of National Academy of Medical Sciences of Ukraine», Kharkiv;

关键词: glycemic memory;    epigenetics;    diabetes mellitus;    vascular complications;   

DOI  :  10.22141/2224-0721.3.59.2014.76598

来源: DOAJ

【 摘 要 】

Prevention/delay of the development of vascular complications remains one of major challenges in treatment of diabetes mellitus. Epidemiological studies have shown lack of efficacy of stable glycemic control in patients with long-existing diabetes. This phenomenon, confirmed in animal models and analyzed at the molecular genetic level, is called metabolic/glycemic memory and associated with epigenetic modifications of gene expression. On the other hand, it has been proven that early intensive intervention in type 1 and 2 diabetes mellitus reduces the risk of micro- and macrovascular complications development and progression, forming the basis for long-term favorable effects that persist beyond normoglycemia. The foregoing justifies change of therapeutic approach in diabetes mellitus since the moment of establishing diagnosis for the early and maximum safely achievement of blood glucose and glycosylated hemoglobin levels close to normal ones.

【 授权许可】

Unknown