The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder

Frontiers in Pharmacology

Angélica P. Escobar¹  Andrés E. Chávez¹  Jens R. Wendland¹  Pablo R. Moya² 

[1] Centro Interdisciplinario de Neurociencia de Valparaíso CINV, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile;Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaiso, Chile;

关键词: EAAT3;    OCD;    obsessive-compulsive disorder;    glutamate transporter;    synaptic function;    NMDAR;   

DOI  :  10.3389/fphar.2019.01362

来源: DOAJ

【 摘 要 】

Obsessive compulsive disorder (OCD) is a heterogeneous psychiatric disorder affecting 1%–3% of the population worldwide. About half of OCD afflicted individuals do not respond to currently available pharmacotherapy, which is mainly based on serotonin reuptake inhibition. Therefore, there is a critical need to search novel and improved therapeutic targets to treat this devastating disorder. In recent years, accumulating evidence has supported the glutamatergic hypothesis of OCD, and particularly pointing a potential role for the neuronal glutamate transporter EAAT3. This mini-review summarizes recent findings regarding the neurobiological basis of OCD, with an emphasis on the glutamatergic neurotransmission and EAAT3 as a key player in OCD etiology.

【 授权许可】

Unknown