The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma

Cancers

Yazhen Zhu¹  Icy Y. Liang¹  Hsian-Rong Tseng¹  Yi-Te Lee¹  Jasmine J. Wang²  Benjamin V. Tran³  Vatche G. Agopian³  Ju Dong Yang⁴  Sungyong You⁴ 

[1] California NanoSystems Institute, Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095, USA;Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA;Department of Surgery, University of California, Los Angeles, CA 90095, USA;Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;

关键词: hepatocellular carcinoma;    extracellular vesicles;    disease progression;    cancer detection;    biomarker;    liquid biopsy;   

DOI  :  10.3390/cancers13123076

来源: DOAJ

【 摘 要 】

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and one of the leading causes of cancer-related death worldwide. Despite the improvements in surveillance and treatment, the prognosis of HCC remains poor. Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles circulating in the bloodstream and mediating intercellular communication. Emerging studies have shown that EVs play a crucial role in regulating the proliferation, immune escape, and metastasis of HCC. In addition, because EVs are present in the circulation at relatively early stages of disease, they are getting attention as an attractive biomarker for HCC detection. Over the past decade, dedicated efforts have been made to isolate EVs more efficiently and make them useful tools in different clinical settings. In this review article, we provide an overview of the EVs isolation methods and highlight the role of EVs as mediators in the pathogenesis and progression of HCC. Lastly, we summarize the potential applications of EVs in early-stage HCC detection.

【 授权许可】

Unknown