Impact of acute kidney injury on mortality in patients with acute variceal bleeding

BMC Gastroenterology

Chang Bin Im¹  Hyun Jin Kim²  Ok-Jae Lee²  Chang Yoon Ha²  Jae Heon Kim²  Woon Tae Jung²  Ra Ri Cha²  Hee Jin Kim²  Hankyu Jeon²  Tae Hyo Kim²  Jae Min Lee²  Jung Woo Choi²  Sang Soo Lee²  Hyun Chin Cho² 

[1] Department of Internal Medicine, Gyeongsang National University Changwon Hospital;Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine;

关键词: Acute kidney injury;    Liver cirrhosis;    Acute variceal bleeding;    Mortality;    International Club of Ascites criteria;   

DOI  :  10.1186/s12876-021-01862-x

来源: DOAJ

【 摘 要 】

Abstract Background The effect of acute kidney injury (AKI) on patients with acute variceal bleeding (AVB) using the recently proposed International Club of Ascites (ICA) criteria is unclear. This study aimed to evaluate the incidence of AKI using the ICA criteria and factors associated with the outcomes in cirrhotic patients with AVB. Methods This retrospective cohort study included data of cirrhotic patients with AVB from two centers in Korea. The association of the ICA criteria for AKI with 6-week mortality was analyzed through univariate and multivariate analyses using the Cox proportional hazard model. Results In total, there were 546 episodes of AVB in 390 patients, of which 425 and 121 episodes were due to esophageal and gastric variceal bleeding, respectively. Moreover, 153 patients fulfilled the ICA criteria for AKI, and 64, 30, 39, and 20 patients were diagnosed with stages 1a, 1b, 2, and 3, respectively. Conversely, 97 patients developed AKI within 42 days as per the conventional criteria. The 6-week mortality rate was significantly higher in patients with ICA-AKI than in patients without ICA-AKI; the occurrence of ICA-AKI was an independent factor for predicting the 6-week mortality. Conclusion The ICA criteria could help diagnose renal dysfunction earlier, and presence of AKI is a predictor of mortality in patients with cirrhosis and AVB.

【 授权许可】

Unknown