The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation

Journal of Clinical Medicine

Juqian Zhang¹  Gregory Y.H. Lip¹  Christophe Saint Etienne²  Jad Boumhidi²  Anne Bernard²  Arnaud Bisson²  Julien Herbert²  Laurent Fauchier² 

[1] Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital, University of Liverpool, Liverpool L69 7ZX, UK;Service de Cardiologie, Centre Hospitalier Universitaire et Faculté de Médecine, Université de Tours, CEDEX 1, 37044 Tours, France;

关键词: transcatheter aortic valve implantation;    mitral regurgitation;    tricuspid regurgitation;    all-cause mortality;    cardiovascular mortality;   

DOI  :  10.3390/jcm10173974

来源: DOAJ

【 摘 要 】

Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. Methods: Adult patients who underwent TAVI were identified in the French National Hospital Discharge Database. All-cause and cardiovascular mortality, stroke, and rehospitalization with heart failure (HF) were compared in TAVI patients with and without baseline MR and tricuspid regurgitation (TR), respectively; the associations of MR and TR with the outcomes were assessed by Cox regression. Results: Baseline MR was identified in 8240 TAVI patients. Patients with baseline MR have higher yearly incidence of all-cause mortality (HR: 1.192, 95% confidence interval CI: 1.125–1.263), cardiovascular mortality (HR: 1.313, 95%CI: 1.210–1.425), and rehospitalization for heart failure (HF) (HR: 1.411, 95%CI: 1.340–1.486) compared to those without, except for stroke rate (HR: 0.988, 95%CI: 0.868–1.124). Neither baseline MR nor TR was an independent risk predictor for all-cause mortality or cardiovascular mortality in TAVI patients. Baseline MR was independently associated with rehospitalization for HF in TAVI patients. Conclusions: Baseline MR and TR were associated with increased all-cause and cardiovascular mortality post-TAVI, however, neither of them was independent predictor for all-cause or cardiovascular mortality.

【 授权许可】

Unknown