3D-printed porous titanium scaffolds incorporating niobium for high bone regeneration capacity

Materials & Design

Xiaobo Feng¹  Changjun Han²  Hang Liang²  Xiangyu Deng²  Liang Ma²  Qingsong Wei³  Danlei Zhao⁴  Cao Yang⁴ 

[1] Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Singapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, 639798, Singapore;;State Key Lab of Materials Processing and Die &

关键词: Bio-functionalization;    Additive manufacturing;    Titanium-niobium;    Macrophage polarization;    Immunomodulation;    Bone regeneration;   

DOI  :  

来源: DOAJ

【 摘 要 】

Biomimetic functionalization is a pressing need for orthopedic implants to achieve reinforced osseointegration and accelerated osteogenesis, thereby obtaining a successful clinical outcome. To realize bioactivity, TiNb alloys with varying Nb contents (0–45 at.%) were additively manufactured using elemental powder blends. The regulation of the Nb contents could balance the surface constituent ratio of Nb2O5 and TiO2, enhancing the formation of the hydroxyl group and surface hydrophilicity. Moreover, the effect mechanism of Nb2O5 on immune modulation and bone regeneration was first put forward. The incorporation of Nb improved the viability of macrophages by inducing a macrophage polarization toward an anti-inflammatory M2-like state. The variation of morphological and up-regulated expression of anti-inflammatory factors led to a more favorable osteoimmune microenvironment for osteogenesis, promoting the osteogenic differentiation of osteoblasts in vitro. Considering the surface constituent and in vitro biological performance, 3D-printed Ti25Nb scaffolds were placed into the femoral condyle of the rabbit. The Micro-CT and histological analysis indicated that Ti25Nb scaffolds could accelerate bone regeneration and reinforce bone integration as relative to pure Ti. Overall, the Ti25Nb scaffold exhibited structural bionic ability, surprising immunomodulatory properties, superior bone regeneration and osseointegration capacity, showing exceptional potential in the treatment of bone defects.

【 授权许可】

Unknown