Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects

Frontiers in Oncology

Xiaosong Xiang¹  Bing Feng²  Hao Zhou²  Ting Wang²  Xinrong Lin²  Xiaoyuan Chu²  Rui Wang² 

[1] Affiliated Jingling Hospital Research Institution of General Surgery, School of Medicine, Nanjing University, Nanjing, China;Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China;

关键词: long non-coding RNA;    hepatocellular carcinoma;    signaling pathway;    therapy resistance;    clinical transformation;   

DOI  :  10.3389/fonc.2021.670838

来源: DOAJ

【 摘 要 】

Hepatocellular carcinoma is the fifth-ranked cancer worldwide with a relatively low five-year survival rate. Long non-coding RNAs are a group of RNAs with remarkable aberrant expression which could act on multiple bioprocesses and ultimately impact upon tumor proliferation, invasion, migration, metastasis, apoptosis, and therapy resistance in cancer cells including hepatocellular carcinoma cells. In recent years, long non-coding RNAs have been reported to be indispensable targets in clinical target therapy to stop the growth of cancer and prolong the lifespan of patients with hepatocellular carcinoma. In this review, we enumerate the signaling pathways and life activities affected by long non-coding RNAs in hepatocellular carcinoma cells to illustrate the role of long non-coding RNAs in the development and therapy resistance of hepatocellular carcinoma.

【 授权许可】

Unknown