Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer

Cancers

Hideo Yanai¹  Munetaka Nakamura²  Sho Sasaki²  Isao Sakaida²  Yuki Kobayashi³  Jun Nishikawa³  Kanami Shimokuri³  Hisashi Iizasa⁴  Hironori Yoshiyama⁴  Takahiro Yamasaki⁵  Kohei Sakai⁵  Yutaka Suehiro⁵ 

[1] Department of Clinical Research, National Hospital Organization Kanmon Medical Center, 1-1 Sotoura, Chofu, Shimonoseki, Yamaguchi 752-8510, Japan;Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan;Department of Laboratory Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan;Department of Microbiology, Shimane University Faculty of Medicine, 89-1 Enyacho, Izumo, Shimane 693-8501, Japan;Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan;

关键词: Epstein–Barr virus;    gastric carcinoma;    DNA methylation;    programed cell death 1 (PD-1);    programmed cell death ligand 1 (PD-L1);    immune checkpoint inhibitor;    endoscopic mucosal resection (EMR);    endoscopic submucosal dissection (ESD);   

DOI  :  10.3390/cancers10060167

来源: DOAJ

【 摘 要 】

Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared with EBV-negative gastric cancer, resulting in a better prognosis. The Cancer Genome Atlas of gastric adenocarcinomas proposed a molecular classification divided into four molecular subtypes: (1) EBVaGC; (2) microsatellite instability; (3) chromosomal instability; and (4) genomically stable tumors. EBVaGC harbors a DNA methylation phenotype, PD-L1 and PD-L2 overexpression, and frequent alterations in the PIK3CA gene. We review clinical importance of EBVaGC and discuss novel therapeutic applications for EBVaGC.

【 授权许可】

Unknown