Spatial Distribution and Burden of Emerging Arboviruses in French Guiana

Viruses

Dominique Rousset¹  Antoine Enfissi¹  Anne Lavergne¹  Sarrah Ben Achour¹  Léna Berthelot¹  Sandrine Fernandes-Pellerin²  Jean-Claude Manuguerra³  Jessica Vanhomwegen³  Camille Fritzell⁴  Claude Flamand⁴  Sarah Bailly⁴  Mona Saout⁴  Félix Djossou⁵  Simon Cauchemez⁶  Nathanaël Hozé⁶  Henrik Salje⁶  Jean-François Carod⁷ 

[1] Arbovirus National Reference Center, Institut Pasteur in French Guiana, 97300 Cayenne, French Guiana;Clinical Coordination of Translational Research Center, Institut Pasteur, 75015 Paris, France;Environment and Infectious Risks Unit, Institut Pasteur, 75015 Paris, France;Epidemiology Unit, Institut Pasteur in French Guiana, 97300 Cayenne, French Guiana;Infectious and Tropical Diseases Unit, Centre Hospitalier Andrée Rosemon, 97300 Cayenne, French Guiana;Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, 75015 Paris, France;Medical Laboratory, Centre Hospitalier de l’Ouest Guyanais, 97320 Saint-Laurent du Maroni, French Guiana;

关键词: arboviruses;    Dengue;    Zika;    Chikungunya;    Mayaro;    prevalence studies;   

DOI  :  10.3390/v13071299

来源: DOAJ

【 摘 要 】

Despite the health, social and economic impact of arboviruses in French Guiana, very little is known about the extent to which infection burden is shared between individuals. We conducted a large multiplexed serological survey among 2697 individuals from June to October 2017. All serum samples were tested for IgG antibodies against DENV, CHIKV, ZIKV and MAYV using a recombinant antigen-based microsphere immunoassay with a subset further evaluated through anti-ZIKV microneutralization tests. The overall DENV seroprevalence was estimated at 73.1% (70.6–75.4) in the whole territory with estimations by serotype at 68.9% for DENV-1, 38.8% for DENV-2, 42.3% for DENV-3, and 56.1% for DENV-4. The overall seroprevalence of CHIKV, ZIKV and MAYV antibodies was 20.3% (17.7–23.1), 23.3% (20.9–25.9) and 3.3% (2.7–4.1), respectively. We provide a consistent overview of the burden of emerging arboviruses in French Guiana, with useful findings for risk mapping, future prevention and control programs. The majority of the population remains susceptible to CHIKV and ZIKV, which could potentially facilitate the risk of further re-emergences. Our results underscore the need to strengthen MAYV surveillance in order to rapidly detect any substantial changes in MAYV circulation patterns.

【 授权许可】

Unknown