Pancreatic β Cell Mass Death

Frontiers in Pharmacology

Salma Ibraheem Alsunousi¹  Husnia I Marrif¹ 

[1] Benghazi University;

关键词: Acinar Cells;    Apoptosis;    Hyperglycemia;    Insulin;    Stem Cells;    differentiation;   

DOI  :  10.3389/fphar.2016.00083

来源: DOAJ

【 摘 要 】

Diabetes is a challenging metabolic disorder for which a cure has not yet been found. Its etiology is associated with two phenomena: a significant loss of the insulin-producing beta cell (β cells) mass and a progressively programmed cell death. Current research in diabetes, however, has taken a different direction; one that moves from compensatory attempts to increase insulin secretion to one that seeks to develop a deep understanding of how to enhance cell survival, decrease apoptosis and replenish β cell mass. The goal of this review is to cover the current knowledge of pancreatic cell development, β cell mass formation and death.

【 授权许可】

Unknown