Muscular Function as an Alternative to Identify Cognitive Impairment: A Secondary Analysis From SABE Colombia

Frontiers in Neurology

Felipe Botero-Rodríguez²  Francisco Lopera³  Alberto Jaramillo-Jimenez⁵  Felipe Ramirez Velandia⁶  Geronimo Gelvis-Ortiz⁶  María-Fernanda Acosta⁶  Isabel Marquez⁶  Carlos Alberto Cano-Gutiérrez⁸  Elkin Garcia-Cifuentes⁹  Angela Iragorri⁹ 

[1] Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway;Departamento de Epidemiologia Clínica y Bioestadística, Pontificia Universidad Javeriana, Bogotá, Colombia;Facultad de Medicina, Grupo Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia;Facultad de Medicina, Grupo Neuropsicología y Conducta, Universidad de Antioquia, Medellín, Colombia;Facultad de Medicina, Semillero de Investigación SINAPSIS, Universidad de Antioquia, Medellín, Colombia;Facultad de Medicina, Semillero de Neurociencias y Envejecimiento, Instituto de Envejecimiento, Pontificia Universidad Javeriana, Bogotá, Colombia;Faculty of Health Sciences, University of Stavanger, Stavanger, Norway;Unidad de Geriatría, Hospital Universitario San Ignacio, Bogotá, Colombia;Unidad de Neurología, Hospital Universitario San Ignacio, Bogotá, Colombia;

关键词: gait speed;    handgrip strength;    cognitive impairment;    biomarker;    pre-clinical dementia;    motor dysfunction;   

DOI  :  10.3389/fneur.2022.695253

来源: DOAJ

【 摘 要 】

BackgroundIdentification of cognitive impairment is based traditionally on the neuropsychological tests and biomarkers that are not available widely. This study aimed to establish the association between motor function (gait speed and handgrip strength) and cognitive performance in the Mini-Mental State Examination, globally and by domains. A secondary goal was calculating a cut-off point for gait speed and handgrip strength to classify older adults as cognitively impaired.MethodsThis is a secondary analysis of SABE Colombia (Salud, Bienestar & Envejecimiento), a survey that was conducted in 2015 on health, wellbeing, and aging in Colombia. This study used linear regression models to search for an association between motor function and cognitive performance. The accuracy of motor function measurements in identifying cognitive impairment was assessed with receiver operating characteristic (ROC) curves. This study also analyzed other clinical and sociodemographical variables.ResultsGait speed was associated with orientation (r2 = 0.16), language (r2 = 0.15), recall memory (r2 = 0.14), and counting (r2 = 0.08). Similarly, handgrip strength was associated with orientation (r2 = 0.175), language (r2 = 0.164), recall memory (r2 = 0.137), and counting (r2 = 0.08). To differentiate older adults with and without cognitive impairment, a gait speed cut-off point of 0.59 m/s had an area under the curve (AUC) of 0.629 (0.613–0.646), and a weak handgrip (strength below 17.5 kg) had an AUC of 0.653 (0.645-0.661). The cut-off points for handgrip strength and gait speed were significantly higher in male participants.ConclusionsGait speed and handgrip strength are similarly associated with the cognitive performance, exhibiting the most extensive association with orientation and language domains of the Mini-Mental State Examination. Gait speed and handgrip strength can easily be measured by any clinician, and they prove to be useful screening tools to detect cognitive impairment.

【 授权许可】

Unknown