Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy

OncoImmunology

Begoña Martin-Castillo¹  Sara Verdura²  Elisabet Cuyàs²  Javier A. Menendez² 

[1] Catalan Institute of Oncology;Metabolism and Cancer Group, Catalan Institute of Oncology;

关键词: metformin;    immunotherapy;    t-cells;    immune checkpoints;   

DOI  :  10.1080/2162402X.2019.1633235

来源: DOAJ

【 摘 要 】

The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve this conundrum and beneficially impact the state of cancer-immune system interactions.

【 授权许可】

Unknown