Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo

Frontiers in Neurology

Yasue Uchida¹  Michihiko Sone²  Masaaki Teranishi²  Takafumi Nakada³  Hirokazu Suzuki³  Saiko Sugiura³ 

[1] Department of Otorhinolaryngology, Aichi Medical University, Nagakute, Japan;Department of Otorhinolaryngology, Nagoya University, Nagoya, Japan;Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Japan;

关键词: benign paroxysmal positional vertigo;    vitamin D;    canalolithiasis;    geotropic;    cupulolithiasis;    apogeotropic;   

DOI  :  10.3389/fneur.2019.00176

来源: DOAJ

【 摘 要 】

Background and Purpose: In the horizontal canal benign paroxysmal positional vertigo (BPPV), cupulolithiasis shows apogeotropic direction changing nystagmus lasting more than 1 min, while canalolithiasis leads to geotropic direction changing nystagmus lasting < 1 min. The difference between cupulolithiasis and canalolithiasis is widely accepted to be the attachment of the displaced otoconia to the cupula of a semicircular canal. Several studies have shown a relationship between BPPV and vitamin D deficiency, but no studies have compared serum levels of vitamin D between canalolithiasis and cupulolithiasis patients. The purpose of this study was to clarify the difference in vitamin D serum level between canalolithiasis and cupulolithiasis of the horizontal canal.Methods: This retrospective study included 20 and 15 patients with canalolithiasis and cupulolithiasis of the horizontal canal, respectively. Serum levels of 25-hydroxyvitamin D [25(OH)D] during the acute phase of BPPV were measured.Results: The mean 25(OH)D serum level in patients with canalolithiasis and cupulolithiasis was 13.2 ± 1.4 and 20.4 ± 1.6 ng/mL, respectively, and the difference was statistically significant (p = 0.0014), also after adjusting for age and sex (p = 0.0351). Eighteen out of 20 (90%) and 5 of 15 (33%) patients were diagnosed with vitamin D deficiency in the canalolithiasis and cupulolithiasis groups, respectively, and this difference was also statistically significant (p = 0.0005).Conclusion: We found that serum vitamin D level in patients with canalolithiasis was significantly lower than that in patients with cupulolithiasis of the horizontal canal.

【 授权许可】

Unknown