期刊论文详细信息
PeerJ
Pattern classification of brain activation during emotional processing in subclinical depression: psychosis proneness as potential confounding factor
Andre Aleman1  William Pettersson-Yeo2  Andrea Mechelli2  Paul Allen2  Gemma Modinos2  Philip McGuire2 
[1] Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, The Netherlands;Department of Psychosis Studies, Institute of Psychiatry, King’s College London, London, United Kingdom;
关键词: Machine learning;    Support vector machine;    fMRI;    Emotion;    Subclinical depression;    Psychosis proneness;   
DOI  :  10.7717/peerj.42
来源: DOAJ
【 摘 要 】

We used Support Vector Machine (SVM) to perform multivariate pattern classification based on brain activation during emotional processing in healthy participants with subclinical depressive symptoms. Six-hundred undergraduate students completed the Beck Depression Inventory II (BDI-II). Two groups were subsequently formed: (i) subclinical (mild) mood disturbance (n = 17) and (ii) no mood disturbance (n = 17). Participants also completed a self-report questionnaire on subclinical psychotic symptoms, the Community Assessment of Psychic Experiences Questionnaire (CAPE) positive subscale. The functional magnetic resonance imaging (fMRI) paradigm entailed passive viewing of negative emotional and neutral scenes. The pattern of brain activity during emotional processing allowed correct group classification with an overall accuracy of 77% (p = 0.002), within a network of regions including the amygdala, insula, anterior cingulate cortex and medial prefrontal cortex. However, further analysis suggested that the classification accuracy could also be explained by subclinical psychotic symptom scores (correlation with SVM weights r = 0.459, p = 0.006). Psychosis proneness may thus be a confounding factor for neuroimaging studies in subclinical depression.

【 授权许可】

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