Targeting Membrane Trafficking as a Strategy for Cancer Treatment

Vaccines

Nydia Tejeda-Muñoz¹  Julia Monka¹  Pooja Sheladiya¹  Kuo-Ching Mei² 

[1] Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA;Division of Pharmacoengineering and Molecular School Pharmaceutics, Eshelman of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;

关键词: macropinocytosis;    Wnt signaling;    membrane trafficking;    V-ATPase;    MVBs;   

DOI  :  10.3390/vaccines10050790

来源: DOAJ

【 摘 要 】

Membrane trafficking is emerging as an attractive therapeutic strategy for cancer. Recent reports have found a connection between Wnt signaling, receptor-mediated endocytosis, V-ATPase, lysosomal activity, and macropinocytosis through the canonical Wnt pathway. In macropinocytic cells, a massive internalization of the plasma membrane can lead to the loss of cell-surface cadherins, integrins, and other antigens that mediate cell–cell adhesion, favoring an invasive phenotype. V-ATPase is a key regulator in maintaining proper membrane trafficking, homeostasis, and the earliest developmental decisions in the Xenopus vertebrate development model system. Here, we review how the interference of membrane trafficking with membrane trafficking inhibitors might be clinically relevant in humans.

【 授权许可】

Unknown