Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens

Journal of Fungi

Yiling Lai¹  Lili Wang¹  Sibao Wang¹  Weilu Zheng¹ 

[1] CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences (CAS), Shanghai 200032, China;

关键词: filamentous fungal pathogens;    histone methylation;    histone acetylation;    fungal pathogenicity;    pathogenic fungi–host interactions;   

DOI  :  10.3390/jof8060565

来源: DOAJ

【 摘 要 】

Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts including plants and insects. The dynamic infection process requires rapid and fine-tuning regulation of fungal gene expression programs in response to the changing host environment and defenses. Therefore, transcriptional reprogramming of fungal pathogens is critical for fungal development and pathogenicity. Histone post-translational modification, one of the main mechanisms of epigenetic regulation, has been shown to play an important role in the regulation of gene expressions, and is involved in, e.g., fungal development, infection-related morphogenesis, environmental stress responses, biosynthesis of secondary metabolites, and pathogenicity. This review highlights recent findings and insights into regulatory mechanisms of histone methylation and acetylation in fungal development and pathogenicity, as well as their roles in modulating pathogenic fungi–host interactions.

【 授权许可】

Unknown