Biomaterials for Cell-Surface Engineering and Their Efficacy

Journal of Functional Biomaterials

Tong In Oh¹  Jin Gil Jeong²  Seoyoung Jang²  EunAh Lee³ 

[1] Department of Biomedical Engineering, School of Medicine, Seoul Campus, Kyung Hee University, Seoul 02447, Korea;Department of Medical Engineering, Graduate School, Seoul Campus, Kyung Hee University, Seoul 02447, Korea;Impedance Imaging Research Center, Seoul Campus, Kyung Hee University, Seoul 02447, Korea;

关键词: stem cells;    encapsulation;    cell therapy;    cyto-protective effect;    cell surface modification;   

DOI  :  10.3390/jfb12030041

来源: DOAJ

【 摘 要 】

Literature in the field of stem cell therapy indicates that, when stem cells in a state of single-cell suspension are injected systemically, they show poor in vivo survival, while such cells show robust cell survival and regeneration activity when transplanted in the state of being attached on a biomaterial surface. Although an attachment-deprived state induces anoikis, when cell-surface engineering technology was adopted for stem cells in a single-cell suspension state, cell survival and regenerative activity dramatically improved. The biochemical signal coming from ECM (extracellular matrix) molecules activates the cell survival signal transduction pathway and prevents anoikis. According to the target disease, various therapeutic cells can be engineered to improve their survival and regenerative activity, and there are several types of biomaterials available for cell-surface engineering. In this review, biomaterial types and application strategies for cell-surface engineering are presented along with their expected efficacy.

【 授权许可】

Unknown