Lipoprotein(a) and Pulmonary Embolism Severity-A Retrospective Data Analysis

Frontiers in Cardiovascular Medicine

Katharina Gütl¹  Reinhard B. Raggam¹  Philipp Jud¹  Günther Silbernagel¹  Marianne Brodmann¹  Moritz Pechtold¹  Thomas Gary¹  Viktoria Muster¹  Paul Gressenberger¹  Ewald Kolesnik²  Johannes Schmid³  Jakob Riedl⁴  Florian Posch⁴ 

[1]Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

[2]Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

[3]Division of General Radiology, Department of Radiology, Medical University of Graz, Graz, Austria

[4]Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

关键词: Lipoprotein(a);    pulmonary embolism;    severity;    venous thromboembolism;    Lp(a);   

DOI  :  10.3389/fcvm.2022.808605

来源: DOAJ

【 摘 要 】

AimWe aimed to investigate a correlation between PE severity and Lp(a) levels.MethodsWe performed a retrospective data analysis from our medical records of PE patients admitted to the University Hospital Graz, Austria. Patients with an Lp(a) reading within a 1-year interval before and after PE diagnosis were included. In accordance with the 2019 ESC guidelines for the diagnosis and management of acute PE, severity assessment was carried out classifying patients into four groups: low risk (LR), intermediate low risk (IML), intermediate high risk (IMH) and high risk (HR). The study period of interest was between January 1, 2002 and August 1, 2020.ResultsWe analyzed 811 patients with PE, of whom 323 (40%) had low-risk PE, 343 (42%) had intermediate-low-risk PE, 64 (8%) had intermediate-high-risk PE, and 81 (10%) had high-risk PE, respectively. We did not observe an association between PE severity and Lp(a) concentrations. In detail, median Lp(a) concentrations were 17 mg/dL [25–75th percentile: 10-37] in low-risk PE patients, 16 mg/dL [10–37] in intermediate-low-risk PE patients, 15mg/dL [10–48] in intermediate-high-risk PE patients, and 13mg/dL [10–27] in high-risk PE patients, respectively (Kruskal-Wallis p = 0.658, p for linear trend = 0.358).ConclusionThe current findings suggest no correlation between PE severity and Lp(a) levels.

【 授权许可】

Unknown