Fatigue after initiating rivaroxaban for venous thromboembolism

Research and Practice in Thrombosis and Haemostasis

Kristin Utne¹  Eli Førsund²  Lars‐Petter Jelsness‐Jørgensen²  Waleed Ghanima²  Tina Margrethe Karlsvik²  Mirjam Aadalen³  René Holst³  Camilla Tøvik Jørgensen³  Thore Langfeldt Borgenvik⁴ 

[1] Department of Hematology‐oncology Østfold Hospital Trust Grålum Norway;Department of Internal Medicine Østfold Hospital Trust Grålum Norway;Department of Research Østfold Hospital Trust Grålum Norway;Department of Surgery Østfold Hospital Trust Grålum Norway;

关键词: anticoagulants;    fatigue;    pulmonary embolism;    rivaroxaban;    thrombosis;    venous thromboembolism;   

DOI  :  10.1002/rth2.12312

来源: DOAJ

【 摘 要 】

Abstract Background Rivaroxaban was the first new oral anticoagulant approved for treatment of venous thromboembolism (VTE). Clinical trials have shown that rivaroxaban is noninferior to conventional anticoagulation for VTE in efficacy and safety. Increased fatigue after the initiation of rivaroxaban has been observed in clinical practice, but data on this potential side effect are lacking. Objective The study aimed to evaluate development of fatigue in patients treated for VTE, comparing rivaroxaban to other anticoagulants. Methods Patients were prospectively recruited after a diagnosis of VTE. The Fatigue Questionnaire was used to determine the level of fatigue at baseline, at 3 weeks of treatment, and either at 1 month after the discontinuation of treatment if the treatment was discontinued after 3 months or at 6 months if treatment was continued beyond this time. Data was analyzed by a linear mixed model. Results A total of 126 patients were included. Mean age was 59 years; 77 (61%) were males. Fifty‐seven patients (45%) were diagnosed with deep vein thrombosis, 48 (38%) with pulmonary embolism, and 21 (17%) with both. Predicted changes in fatigue scores from baseline to the last measurement were −0.007 and −2.49 for the rivaroxaban and the other‐anticoagulants groups, respectively, neither of which were statistically significant. No difference was detected between rivaroxaban and the other‐anticoagulants group at any time point, including subgroup analysis comparing over and under 6 months of treatment duration. Conclusion In this small study, our results suggest no increase in the level of fatigue after the initiation of treatment with rivaroxaban for VTE.

【 授权许可】

Unknown