Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries

Molecules

Jonghoon Kim¹  Taegwan Kim¹  Min Woo Ha² 

[1] Department of Chemistry, Soongsil University, 369 Sangdo-ro, Seoul 06978, Korea;Jeju Research Institute of Pharmaceutical Sciences, College of Pharmacy, Jeju National University, 102 Jejudaehak-ro, Jeju 63243, Korea;

关键词: natural products;    indole;    small-molecule library;    diversity-oriented synthesis;    complexity-to-diversity (Ctd) strategy;    biomimetic synthesis;   

DOI  :  10.3390/molecules27072171

来源: DOAJ

【 摘 要 】

Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-molecule libraries.

【 授权许可】

Unknown