Normothermic and hypothermic oxygenated perfusion for donation after circulatory death in kidney transplantation: do we pay higher risk of severe infection after transplantation?: a case report

BMC Infectious Diseases

Raffaele Bova¹  Giuliana Germinario¹  Anna Paola Pezzuto¹  Federica Odaldi¹  Daniele Parlanti¹  Guido Fallani¹  Matteo Ravaioli¹  Lorenzo Maroni¹  Claudia Bini²  Valeria Corradetti²  Gaetano La Manna²  Giorgia Comai²  Matteo Renzulli³ 

[1] Department of General Surgery and Transplantation, Sant’Orsola- Malpighi Hospital, University of Bologna;Department of Nephrology, S.Orsola- Malpighi Hospital, University of Bologna;Department of Radiology, S.Orsola- Malpighi Hospital, University of Bologna;

关键词: Transplant;    Infections;    Arteritis;    Candida krusei;    Pseudomonas aeruginosa;   

DOI  :  10.1186/s12879-020-4835-0

来源: DOAJ

【 摘 要 】

Abstract Background Normothermic and hypothermic oxygenated perfusion for donation after circulatory death in kidney transplantation are becoming popular in Italy, with the purpose of reducing the risk of primary non function and delayed graft function due to the prolonged warm ischemia time. Potential complications related to these procedures are currently under investigation and are continuously emerging with the increasing experience. Post-operative infections - in particular graft arteritis - are a rare complication but determine high risk of mortality and of graft loss. The acute onset of the arterial complications makes it very difficult to find an effective treatment, and early diagnosis is crucial for saving both patient and graft. Prevention of such infections in this particular setting are advisable. Case presentation We present a patient with an acute arterial rupture after transplantation of a DCD graft treated in-vivo hypothermic oxygenated perfusion. The cause was a severe arteritis of the renal artery caused by Candida krusei and Pseudomonas aeruginosa. We discussed our treatment and we compared it to the other reported series. Conclusion Fungal infections in DCD transplant may be treacherous and strategies to prevent them should be advocated.

【 授权许可】

Unknown