Insights into Sensing of Murine Retroviruses

Viruses

SusanR. Ross¹  EileenA. Moran¹ 

[1] Department of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, 835 S. Wolcott Avenue, Chicago, IL 60612, USA;

关键词: murine leukemia virus;    mouse mammary tumor virus;    PRR;    PAMP;    ALR;    TLR;   

DOI  :  10.3390/v12080836

来源: DOAJ

【 摘 要 】

Retroviruses are major causes of disease in animals and human. Better understanding of the initial host immune response to these viruses could provide insight into how to limit infection. Mouse retroviruses that are endemic in their hosts provide an important genetic tool to dissect the different arms of the innate immune system that recognize retroviruses as foreign. Here, we review what is known about the major branches of the innate immune system that respond to mouse retrovirus infection, Toll-like receptors and nucleic acid sensors, and discuss the importance of these responses in activating adaptive immunity and controlling infection.

【 授权许可】

Unknown