Economic impact of a rapid, on‐demand ADAMTS‐13 activity assay for the diagnosis of thrombotic thrombocytopenic purpura

Research and Practice in Thrombosis and Haemostasis

Amanda Stucke¹  Keven Sew²  Rob Cook³  Rosie Martin³  Alicia White³ 

[1] EIU HPCE Practice New York New York USA;EIU HPCE Practice Singapore Singapore;Economist Intelligence Unit (EIU) Health Policy and Clinical Evidence (HPCE) Practice London UK;

关键词: ADAMTS‐13 protein;    cost savings;    plasma exchange;    thrombotic microangiopathies;    thrombotic thrombocytopenic purpura;   

DOI  :  10.1002/rth2.12711

来源: DOAJ

【 摘 要 】

Abstract Background Thrombotic thrombocytopenic purpura (TTP) is a rare, life‐threatening thrombotic microangiopathy (TMA), characterized by ADAMTS‐13 activity <10%. ADAMTS‐13 activity assays are typically performed in reference laboratories with a turnaround time of several days. First‐line treatment for TTP, therapeutic plasma exchange (TPE), typically starts while results are pending. The automated, on‐demand HemosIL AcuStar ADAMTS‐13 Activity assay provides results in under an hour, which could reduce unnecessary TPE use and associated costs. Objectives To estimate the hospital budget impact in the United States, United Kingdom, and France of using a rapid ADAMTS‐13 activity assay. Methods We compared routine use of a rapid assay in adults with TMA with a scenario in which results take 3 days. Model structure and variables were based on published literature, plus survey and interviews of five clinicians from the three countries. Costs for the ADAMTS‐13 activity assays and TPE were included. Results Model results suggest that if an on‐demand, rapid ADAMTS‐13 activity assay is used, US, UK, and French hospitals could save $18 million, £1.2 million, and €1.6 million annually, respectively. This equates to $10 788, £3497, and €4700 saved per patient with TMA in the United States, United Kingdom, and France. The model is most sensitive to the exact split of diagnoses of TMA cases, as savings accrue from non‐TTP diagnoses. Conclusions In patients with TMA, use of a rapid, on‐demand ADAMTS‐13 activity assay such as the HemosIL AcuStar ADAMTS‐13 Activity assay has the potential to be cost saving for hospitals.

【 授权许可】

Unknown