Comparison of Antioxidant and Anti-hyaluronidase Potentials of Pineapple Core Extract (Ananas comosus (L.) Merr.) and Luteolin

Majalah Kedokteran Bandung

Wahyu Setia Widodo¹  Wahyu Widowati²  Delores Elisabeth Sormin³  I Nyoman Ehrich Lister³  Edy Fachrial³  Adek Armansyah³  Ridza Jusri⁴ 

[1] Biomolecular and Biomedicine Research Center, Aretha Medika Utama;Faculty of Medicine, Maranatha Christian University, Bandung, West Java, Indonesia;Faculty of Medicine, Universitas Prima Indonesia, Medan, South Sumatera, Indonesia;Master in Biomedical Science, Faculty of Medicine, Universitas Prima Indoensia;

关键词: antiagin, antioxidants, anti-hyaluronidase, luteolin, pineapple core extract;   

DOI  :  10.15395/mkb.v51n2.1629

来源: DOAJ

【 摘 要 】

Skin aging processes are divided into chronological aging and premature aging. Premature aging is generally caused by free radicals, from both air pollution and photoaging. Natural compounds from plant extracts are among sources of antioxidants and anti-hyaluronidase which have the ability to prevent antiaging. One of the potential fruits related to antioxidant and antiaging activities is Anana scomosus. A. comosus has a number of phenolic compounds with biological activities. One of the main phenolic compounds in A. comosus is luteolin. The aim of this study was to evaluate the antioxidant and antiaging potentials of Pineapple Core Extract (PCE). This study was conducted at the Biomolecular and Biomedicine Research Center, Aretha Medika Utama from August to November 2018. Analysis of antioxidants from PCE and luteolin was carried out using H2O2 scavenging activity assay. The antiaging assay was carried out through inhibition of hyaluronidase enzyme, one of the important enzymes in the aging process. Luteolin had lower IC50 value of H2O2 scavenging activity of around 24.12±3.13 μg/ml, which was better than CPE with IC50 of 304.56±3.76μg/mL. The results of hyaluronidase inhibition activity assay showed that luteolin compound had a lower IC50 value of 67.38±3.99 μg/mL when compared to PCE with an IC50 value of 161.15±1.05 μg/mL. Hence, Luteolin has higher antioxidant and anti-hyaluronidase activities than PCE

【 授权许可】

Unknown