Hypereosinophilia is a predictive biomarker of immune checkpoint inhibitor-induced hypopituitarism in patients with renal cell carcinoma

BMC Endocrine Disorders

Kazuo Hara¹  Rika Saikawa¹  Shunsuke Funazaki¹  Hodaka Yamada¹  Shiori Tonezawa¹  Rie Hagiwara¹  Masashi Yoshida¹  Daisuke Suzuki¹  Satoshi Washino²  Kimitoshi Saito²  Tomoaki Miyagawa²  Tsuzumi Konishi² 

[1] Department of Endocrinology and Metabolism, Jichi Medical University Saitama Medical Center;Department of Urology, Jichi Medical University Saitama Medical Center;

关键词: Immune checkpoint inhibitors;    Immune-related adverse events;    Hypopituitarism;    Renal cell carcinoma;   

DOI  :  10.1186/s12902-022-01024-4

来源: DOAJ

【 摘 要 】

Abstract Background This study aimed to evaluate whether hypereosinophilia is a clinical biomarker of immune checkpoint inhibitor-induced hypopituitarism in patients with renal cell carcinoma treated with nivolumab plus ipilimumab. Methods This was a retrospective cohort study conducted at Jichi Medical University Saitama Medical Center between January 2018 and December 2020. In total, 12 patients with renal cell carcinoma who presented with immune checkpoint inhibitor-induced hypopituitarism were enrolled in this study. The clinical parameters and symptoms at baseline, last visit, and onset of hypopituitarism were analyzed. Results The median period from the initial treatment with immune checkpoint inhibitors to the onset of hypopituitarism was 82.5 (range: 56–196) days. Most patients developed hypopituitarism within 6 months. One patient presented with hypophysitis and 11 patients presented with isolated adrenocorticotropic hormone deficiency. The major symptoms noted at onset were fatigue (66.7%) and loss of appetite (41.7%). None of the patients had symptoms during the last visit. However, four developed hypereosinophilia. Eosinophil fraction (%) and eosinophil count (/µL) increased during the last visit and at the onset of hypopituitarism, respectively. The serum sodium and plasma glucose levels were similar. Conclusions The eosinophil count increased before the onset of hypopituitarism. Thus, hypereosinophilia can be an early predictor of hypopituitarism.

【 授权许可】

Unknown