Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours

BMC Research Notes

On behalf of AOCS¹  Prue Allan²  Richard Lupat³  Maria A. Doyle³  Jason Li³  Kylie L. Gorringe⁴  Genevieve V. Dall⁴  Sally M. Hunter⁴  Simone M. Rowley⁴  David Bowtell⁴  Ian G. Campbell⁴ 

[1] ;Anatomical Pathology, Peter MacCallum Cancer Centre;Bioinformatics Core Facility Peter MacCallum Cancer Centre;Cancer Genomics Program, Peter MacCallum Cancer Centre;

关键词: Ovarian fibroma;    Adenofibroma;    Cystadenomas;    Cystadenofibroma;    Copy number aberrations;    Gene expression;   

DOI  :  10.1186/s13104-020-05194-z

来源: DOAJ

【 摘 要 】

Abstract Objective Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal cells (pure fibroma) or a mixture of fibroblast and epithelial components (adenofibroma). We have previously shown that 40% of benign serous ovarian tumours are likely primary fibromas due to the neoplastic alterations being restricted to the stromal compartment of these tumours. We further explore this finding by comparing benign serous tumours to pure fibromas. Results Performing copy number aberration (CNA) analysis on the stromal component of 45 benign serous tumours and 8 pure fibromas, we have again shown that trisomy of chromosome 12 is the most common aberration in ovarian fibromas. CNAs were more frequent in the pure fibromas than the benign serous tumours (88% vs 33%), however pure fibromas more frequently harboured more than one CNA event compared with benign serous tumours. As these extra CNA events observed in the pure fibromas were unique to this subset our data indicates a unique tumour evolution. Gene expression analysis on the two cohorts was unable to show gene expression changes that differed based on tumour subtype. Exome analysis did not reveal any recurrently mutated genes.

【 授权许可】

Unknown