Persistent Post-Traumatic Headache and Migraine: Pre-Clinical Comparisons

International Journal of Environmental Research and Public Health

Giulia Andolina¹  Martina Curto²  LedaMarina Pomes³  Matilde Capi³  Luana Lionetto⁴  Paolo Martelletti⁵ 

[1] Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98122 Messina, Italy;Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy;Department of Neurosciences, Mental Health & Sensory Organs (NESMOS), Sapienza University of Rome, 00185 Rome, Italy;Mass Spectrometry Lab-Clinical Biochemistry Unit, Sant’Andrea University Hospital, 00189 Rome, Italy;Sant’Andrea Hospital, Regional Referral Headache Centre, 00189 Rome, Italy;

关键词: PTTH;    migraine;    persistent post-traumatic headache;    pathophysiology;    drugs;    traumatic-brain injury;   

DOI  :  10.3390/ijerph17072585

来源: DOAJ

【 摘 要 】

Background: Oftentimes, persistent post traumatic headache (PPTH) and migraine are phenotypically similar and the only clinical feature that differentiate them is the presence of a mild or moderate traumatic brain injury (mTBI). The aim of this study is to describe the differences in brain area and in biochemical cascade after concussion and to define the efficacy and safety of treatments in use. Methods: Sources were chosen in according to the International Classification of Headache Disorder (ICHD) criteria. Results: The articles demonstrated a significant difference between PPTH and migraine regarding static functional connectivity (sFC) and dynamic functional connectivity (dFC) in brain structure that could be used for exploring the pathophysiological mechanisms in PPTH. Many studies described a cascade of neuro-metabolic changes that occur after traumatic brain injury. These variations are associated to the mechanism occurring when developing a PPTH. Conclusions: The state of art of this important topic show how although the mechanisms underlying the development of the two different diseases are different, the treatment of common migraine is efficacious in patients that have developed a post traumatic form.

【 授权许可】

Unknown