Refining the Design of Diblock Elastin-Like Polypeptides for Self-Assembly into Nanoparticles

Polymers

Jan Pille¹  JanC. M. van Hest¹  Xavier Schultze²  Michèle Dai³  Elisabeth Garanger³  Evangelos Georgilis³  Bertrand Garbay³  Sébastien Lecommandoux³  Guillaume Goudounet³ 

[1] Bio-organic Chemistry Lab, Eindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600 MB Eindhoven, The Netherlands;L’Oréal Recherche Avancée, 1 Avenue Eugène Schueller, 93600 Aulnay-sous-Bois, France;University Bordeaux, CNRS, Bordeaux INP, LCPO, UMR 5629, 33600 Pessac, France;

关键词: elastin-like polypeptides;    thermoresponsiveness;    self-assembly;    nanoparticles;    methionine oxidation;   

DOI  :  10.3390/polym13091470

来源: DOAJ

【 摘 要 】

Diblock copolymers based-on elastin-like polypeptide (ELP) have the potential to undergo specific phase transitions when thermally stimulated. This ability is especially suitable to form carriers, micellar structures for instance, for delivering active cargo molecules. Here, we report the design and study of an ELP diblock library based on ELP-[M₁V₃-i]-[I-j]. First, ELP-[M₁V₃-i]-[I-j] (i = 20, 40, 60; j = 20, 90) that showed a similar self-assembly propensity (unimer-to-aggregate transition) as their related monoblocks ELP-[M₁V₃-i] and ELP-[I-j]. By selectively oxidizing methionines of ELP-[M₁V₃-i] within the different diblocks structures, we have been able to access a thermal phase transition with three distinct regimes (unimers, micelles, aggregates) characteristic of well-defined ELP diblocks.

【 授权许可】

Unknown