Evaluation of red blood cell distribution width in patients with psoriatic arthritis

Egyptian Rheumatologist

Sevinc Can Sandikci¹  Cem Ozisler² 

[1] Department of Rheumatology, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey;Corresponding author at: Department of Rheumatology, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Sehit Omer Halisdemir Street, Altindag, Ankara TR-06100, Turkey.;

关键词: C-reactive protein;    Erythrocyte sedimentation rate;    Inflammation;    Psoriatic arthritis;    Red blood cell distribution width;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aim of the work: To evaluate the red blood cell distribution width (RDW) values in psoriatic arthritis (PsA) patients and to study the relationship between these values and disease activation. Patients and methods: Forty seven patients with PsA and 56 age- and sex matched healthy controls were included in this study. Laboratory test results of both groups were retrospectively collected from medical records; these included levels for white blood cell count, hemoglobin, platelet, RDW, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Disease activity score (DAS28) was used to evaluate disease activity. Results: The study comprised 47 PsA patients (32 females and 15 males) (F:M 2.1:1) with a mean age of 39.2 ± 9.9 (20–54) years and mean disease duration was 3.3 ± 1.94 (1–8) years. 39 (83%) patients were receiving monotherapy, 8 (17%) were receiving combined therapy. The RDW values were significantly higher when comparing active disease period (16 ± 3.9) of PsA patients versus inactive disease period (14.2 ± 1.04) and controls (14.03 ± 1.2) (p < 0.001). Otherwise, no significant differences were found when comparing inactive disease period of PsA patients versus controls (p = 0.18). RDW values of active disease period of PsA patients significantly correlated with ESR (r = 0.57, p < 0.001), CRP (r = 0.4, p = 0.006) and DAS28 (r = 0.42, p = 0.003). Conclusions: Increased RDW is associated with active disease period of PsA patients. RDW seems to be a surrogate marker of the inflammation, like CRP and ESR. It is included in the complete blood count thus its measurement does not need any additional costs. RDW may be a potential marker to evaluate disease activity of PsA.

【 授权许可】

Unknown