Octacalcium Phosphate for Bone Tissue Engineering: Synthesis, Modification, and In Vitro Biocompatibility Assessment

International Journal of Molecular Sciences

Anastasia Yu. Teterina¹  Polina V. Smirnova¹  Sergey M. Barinov¹  Igor V. Smirnov¹  Vladislav V. Minaychev¹  Margarita I. Kobyakova¹  Vladimir S. Komlev¹  Aleksandr Yu. Fedotov¹  Irina S. Fadeeva¹  Roman S. Fadeev² 

[1] A.A. Baikov Institute of Metallurgy and Material Science Russian Academy of Sciences, Leninskiy Prospect 49, 117334 Moscow, Russia;Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia;

关键词: biocompatible materials;    calcium phosphate compounds;    hydroxyapatite;    octacalcium phosphate;    bone tissue regeneration;    biomineralization;   

DOI  :  10.3390/ijms222312747

来源: DOAJ

【 摘 要 】

Octacalcium phosphate (OCP, Ca₈H₂(PO₄)₆·5H₂O) is known to be a possible precursor of biological hydroxyapatite formation of organic bone tissue. OCP has higher biocompatibility and osseointegration rate compared to other calcium phosphates. In this work, the synthesis of low-temperature calcium phosphate compounds and substituted forms of those at physiological temperatures is shown. Strontium is used to improve bioactive properties of the material. Strontium was inserted into the OCP structure by ionic substitution in solutions. The processes of phase formation of low-temperature OCP with theoretical substitution of strontium for calcium up to 50 at.% in conditions close to physiological, i.e., temperature 35–37 °C and normal pressure, were described. The effect of strontium substitution range on changes in the crystal lattice of materials, the microstructural features, surface morphology and biological properties in vitro has been established. The results of the study indicate the effectiveness of using strontium in OCP for improving biocompatibility of OCP based composite materials intended for bone repair.

【 授权许可】

Unknown