A study to assess the unmet medical needs associated with the use of basal insulin in patients with type 2 diabetes

Endocrinology, Diabetes & Metabolism

Federico Perez Mangui¹  Gustavo Frechtel²  Cristina Faingold³  Silvia Orio⁴  Julian A. De Luca⁵  María S. Guaita⁵  Norma Vivas⁵  Lujan Forti⁵  Claudia Issa⁶ 

[1] CINME Centro de Investigaciones Metabólicas Buenos Aires Argentina;Division Nutrition and Diabetes Sirio Libanés Hospital Buenos Aires Argentina;Division of Endocrinology Cesar Milstein Hospital Buenos Aires Argentina;IMOBA Investigaciones Médicas Buenos Aires Argentina;SANOFI Buenos Aires Argentina;Sanatorio Guemes Buenos Aires Argentina;

关键词: basal insulin;    HbA1c;    hypoglycaemia;    type 2 diabetes;   

DOI  :  10.1002/edm2.164

来源: DOAJ

【 摘 要 】

Abstract Aim To describe in a real‐world setting, the proportion of patients with a symptomatic hypoglycaemic event and the proportion of individuals with type 2 diabetes, who newly or recently initiated with basal insulin, achieving individual or general HbA1c target. Materials and Method DINAS‐AR was a national prospective observational study to assess the unmet needs in patients with type 2 diabetes treated with basal insulin with or without oral antihyperglycaemic drugs and/or GLP‐1 receptor agonist. The study was conducted at 19 hospitals. Results A total of 385 uncontrolled patients (≥18 years) who recently initiated basal insulin or who initiated treatment within a year prior to study enrolment entered the study. Outcomes were follow‐up incidence of hypoglycaemic events, change of HbA1C and achievement of HBA1c <7% or individual target. A total of 44 patients (11.9%) reported the occurrence of ≥1 symptomatic hypoglycaemia event(s). HbA1c reductions were greater in patients who had recently initiated treatment with basal insulin (between 15 and 90 days prior to study entry) vs patients who initiated treatment within 1 year. A total of 80 patients (31.6%) achieved individual HbA1c target (or target <7.0%) at Week 24. Furthermore, the proportion of patients achieving this target without symptomatic hypoglycaemia was 26.1% (n = 66). A lower percentage of glycemia target achievement was observed in patients reporting hypoglycaemia (n = 14), 20.6% of all patients reporting hypoglycaemia event(s) vs (n = 66) 35.7% of all patients without hypoglycaemia event reported. Conclusion In this real‐world study, although the hypoglycaemia rate was not high in adults with type 2 diabetes treated with insulin, there was a lower percentage of patients that achieved glycemic target among those reporting hypoglycaemia events vs patients who did not report them.

【 授权许可】

Unknown