期刊论文详细信息
Metabolites
Antibiotic-Induced Changes in Microbiome-Related Metabolites and Bile Acids in Rat Plasma
Markus Slopianka1  Philipp Ternes1  Tilmann Walk1  Volker Haake1  Véronique de Bruijn2  Bennard van Ravenzwaay2  Christina Behr2  Saskia Sperber2  Karsten Beekmann3 
[1] BASF Metabolome Solutions, Tegeler Weg 33, 10589 Berlin, Germany;BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany;Division of Toxicology, Wageningen University and Research, 6708 WE Wageningen, The Netherlands;
关键词: microbiome;    bile acids;    metabolomics;    antibiotics;   
DOI  :  10.3390/metabo10060242
来源: DOAJ
【 摘 要 】

Various environmental factors can alter the gut microbiome’s composition and functionality, and modulate host health. In this study, the effects of oral and parenteral administration of two poorly bioavailable antibiotics (i.e., vancomycin and streptomycin) on male Wistar Crl/Wi(Han) rats for 28 days were compared to distinguish between microbiome-derived or -associated and systemic changes in the plasma metabolome. The resulting changes in the plasma metabolome were compared to the effects of a third reference compound, roxithromycin, which is readily bioavailable. A community analysis revealed that the oral administration of vancomycin and roxithromycin in particular leads to an altered microbial population. Antibiotic-induced changes depending on the administration routes were observed in plasma metabolite levels. Indole-3-acetic acid (IAA) and hippuric acid (HA) were identified as key metabolites of microbiome modulation, with HA being the most sensitive. Even though large variations in the plasma bile acid pool between and within rats were observed, the change in microbiome community was observed to alter the composition of the bile acid pool, especially by an accumulation of taurine-conjugated primary bile acids. In-depth investigation of the relationship between microbiome variability and their functionality, with emphasis on the bile acid pool, will be necessary to better assess the potential adverseness of environmentally induced microbiome changes.

【 授权许可】

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