Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature

Nutrients

Klaus Tödter¹  Anna Worthmann¹  Paul Pertzborn¹  Ludger Scheja¹  MiraJ. Pauly¹  Ioannis Evangelakos¹  JuliaK. Rohde¹  Clara John¹  Joerg Heeren¹  AnjaChristina Koop² 

[1] Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;Department of Internal Medicine I, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;

关键词: fiber;    inulin;    short chain fatty acids;    bile acids;    cholestasis;   

DOI  :  10.3390/nu12103200

来源: DOAJ

【 摘 要 】

Dietary fibers are fermented by gut bacteria into the major short chain fatty acids (SCFAs) acetate, propionate, and butyrate. Generally, fiber-rich diets are believed to improve metabolic health. However, recent studies suggest that long-term supplementation with fibers causes changes in hepatic bile acid metabolism, hepatocyte damage, and hepatocellular cancer in dysbiotic mice. Alterations in hepatic bile acid metabolism have also been reported after cold-induced activation of brown adipose tissue. Here, we aim to investigate the effects of short-term dietary inulin supplementation on liver cholesterol and bile acid metabolism in control and cold housed specific pathogen free wild type (WT) mice. We found that short-term inulin feeding lowered plasma cholesterol levels and provoked cholestasis and mild liver damage in WT mice. Of note, inulin feeding caused marked perturbations in bile acid metabolism, which were aggravated by cold treatment. Our studies indicate that even relatively short periods of inulin consumption in mice with an intact gut microbiome have detrimental effects on liver metabolism and function.

【 授权许可】

Unknown