Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction

Frontiers in Physiology

Ulrich Beuers¹  Tilman Sauerbruch²  Martin Hennenberg³  Jonel Trebicka⁴ 

[1] Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, location AMC, Amsterdam, Netherlands;Department of Internal Medicine I, University of Bonn, Bonn, Germany;Department of Urology I, University Hospital, LMU Munich, Munich, Germany;Translational Hepatology, Medical Department, University of Frankfurt, Frankfurt, Germany;

关键词: bile acids;    liver cirrhosis;    portal hypertension;    microbiome;    vasodilation;   

DOI  :  10.3389/fphys.2021.718783

来源: DOAJ

【 摘 要 】

The bile acid pool with its individual bile acids (BA) is modulated in the enterohepatic circulation by the liver as the primary site of synthesis, the motility of the gallbladder and of the intestinal tract, as well as by bacterial enzymes in the intestine. The nuclear receptor farnesoid X receptor (FXR) and Gpbar1 (TGR5) are important set screws in this process. Bile acids have a vasodilatory effect, at least according to in vitro studies. The present review examines the question of the extent to which the increase in bile acids in plasma could be responsible for the hyperdynamic circulatory disturbance of liver cirrhosis and whether modulation of the bile acid pool, for example, via administration of ursodeoxycholic acid (UDCA) or via modulation of the dysbiosis present in liver cirrhosis could influence the hemodynamic disorder of liver cirrhosis. According to our analysis, the evidence for this is limited. Long-term studies on this question are lacking.

【 授权许可】

Unknown