Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities

Acta Pharmaceutica Sinica B

Yuhuan Li¹  Minghua Chen²  Jiandong Jiang²  Yufeng Liu²  Qinglan Guo²  Jiangong Shi² 

[1] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;

关键词: Cruciferae;    Isatis indigotica;    Aromatic metabolite;    Antiviral activity;   

DOI  :  10.1016/j.apsb.2016.09.004

来源: DOAJ

【 摘 要 】

A pair of new diphenyl glycerol ether enantiomers (−)-1 and (+)-1 and two new methyl benzamidobenzoates 2 and 3, named (−)-(R)- and (+)-(S)-isatindigotrioic acid [(−)-1 and (+)-1] and isatindigoticamides A (2) and B (3), respectively, were isolated from an aqueous decoction of the roots of Isatis indigotica (ban lan gen). Their structures were elucidated by spectroscopic data analysis including 2D NMR experiments. The absolute configurations of (−)-1 and (+)-1 were assigned based on the CD exciton chirality method. Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC50 values of 4.87 and 25.87 μmol/L, respectively. Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production.

【 授权许可】

Unknown